MS Defense by Kathryn Murray

Kathryn Murray

Master’s Defense Presentation

 

Date: Tuesday August 15th, 2017

Time: 12:30-2:30pm EST

Location: Engineered Biosystems Building (EBB) room 4029

 

Committee Members:

 

Todd Sulchek, PhD (Advisor, GT ME/BME)

Julie Champion, PhD (GT ChBE)

Ravi Kane, PhD  (GT ChBE/BME)

 

Title:

 

Fabrication and characterization of multifunctional particles with spatially segregated proteins 

 

Abstract:

Multifunctional particles have been of great interest in a variety of fields including electronics, biology, chemistry, and medicine. In therapeutic design, they can allow for site specific targeting, monitoring of delivery as well as the ability to carry multiple immiscible drugs on a single particle at once. Despite the many advances in multifunctional particles, there are still very few methodologies which allow for spatial control of multiple chemical and biological ligands on a single particle. In this thesis, a novel method has been explored to fabricate a three-sided "Cerberus" particle using repeated glancing angle metal evaporation on microparticles. Silica particles of varying diameters are surface-modified with two metals creating chemically distinct regions which possess specific binding interactions allowing spatial segregation of protein on a single particle. Additionally, these particles can possess other non-biological and unique functionalities based on choice of metal, such as magnetic and antimicrobial properties, which have been briefly explored. Overall, this work demonstrates a novel methodology for the creation of a spatially segregated particle platform which is easily reconfigurable, thus allows for multiple types of applications.

Event Details

Date/Time:

  • Tuesday, August 15, 2017
    12:30 pm - 2:30 pm
Location: Engineered Biosystems Building (EBB) room 4029